The team is currently in fourth place with 66 points, just ahead of Chelsea and Aston Villa, and a win at St. James' Park would secure Champions League qualification.
Isak has been making good progress in his recovery and has been training individually, but Howe will make a final decision on his availability for the match on Friday.
Additionally, fullback Kieran Trippier is also a possibility to return to the team after a two-week absence.
Howe emphasized that the team's mindset has been lively and positive this week, with the players looking forward to the challenge against Everton.
The manager expressed confidence in the team's ability to perform consistently and take the opportunity to secure Champions League qualification.
However, he also acknowledged that the match will be difficult and that Everton is a tough opponent, having not conceded many goals recently.
Howe stressed that the team will focus on their own performance and not rely on other results.
If Newcastle achieves Champions League qualification, it would be a significant achievement, especially considering the competition from other teams.
Howe hopes that the team can create another memorable experience, similar to their Carabao Cup win, and make the most of this season's opportunities.