Tottenham sees De Winter as a potential replacement for their player Cristian Romero, who is currently being considered by Atletico Madrid and Real Madrid.
Should Tottenham lose Romero, they may choose to sign De Winter to fill the gap in their defense.
However, De Winter is not the only player being considered by Tottenham, with several other clubs also showing interest in him, including Inter Milan, Crystal Palace, and Bournemouth.
Genoa is willing to sell De Winter to another club for 25 million euros this summer.